研究用MRI共有プラットフォームMRI platform

文部科学省「先端研究基盤共用促進事業」

業績一覧 -2022年度-

トピックス

QST住吉先生と東北大領家先生の共著論文がNature Neuroscienceに掲載されました。
「ラット脳機能連結解析のための国際的標準プロトコールの確立」

Grandjean J, ... Ryoke R, Sumiyoshi A, et al., A consensus protocol for functional connectivity analysis in the rat brain. Nat Neurosci. 2023 Apr;26(4):673-681. doi: 10.1038/s41593-023-01286-8.

本研究は世界から200名を超える研究者が参加した国際大型プロジェクトであります。日本からは東北大学・川島研究室のグループが参加しており、研究成果は神経科学分野のトップジャーナルであるNature Neuroscience誌（IF=28.771）の表紙を飾りました。機能的MRIは内因性ヘモグロビンの酸化還元を利用する神経イメージングのひとつでありトレーサーを使用しない非侵襲的な方法であります。提案されたプロトコルによって得られた機能的MRIのデータは、組織学的な手法を用いたマウス脳神経投射の結果と良く一致することが分かりました。今後はコミュニティにおける汎用的な標準プロトコルとして用いられていくものと考えます。このようなオープンマインドな多施設ネットワーク形成の試みは過去や将来のデータの妥当性を担保する重要な一歩であると考えています。

英文

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16. Iki N, Nakane R, Masuya-Suzuki A, Ozawa Y, Maruoka T, Iiyama M, Sumiyoshi A, Aoki I. MRI Contrasting Agent Based on Mn-MOF-74 Nanoparticles with Coordinatively Unsaturated Sites. Mol Imaging Biol. 2023 Jan 18. doi: 10.1007/s11307-023-01801-0. Epub ahead of print. PMID: 36653627.
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